| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3284384 | Clinical Gastroenterology and Hepatology | 2010 | 7 Pages |
Abstract
In young patients with apparently sporadic CRC, most tumors arise in the distal colon; only 21% have features of Lynch syndrome. Loss of MSH6 or PMS2 occurred in 13.3% of these tumors. Most tumors that lose MSH6 will not be detected in screens for MSI; CRC screening might be modified to identify more patients with Lynch syndrome.
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Authors
Ajay Goel, Takeshi Nagasaka, Jennifer Spiegel, Richard Meyer, Warren E. Lichliter, C. Richard Boland,