| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3286197 | Clinics and Research in Hepatology and Gastroenterology | 2015 | 11 Pages |
SummaryBackgroundChronic rejection (CR) is an important cause of liver allograft failure. In the latter condition, re-transplantation of the liver (ReLT) is the only option for survival. Unfortunately, with the current state of knowledge, it is difficult to diagnose and treat early CR.ObjectiveTo explore the biomarkers of the chronic rejection in orthotopic liver transplantation (OLT).MethodsA rat model of chronic liver allograft rejection was established, and the differential protein expression in chronic allograft rejection (CR) was analyzed by iTRAQ-MALDI-TOF/TOF.ResultsExpression of sixty-two proteins was found to be significantly changed in CR rats. In the present study, CLU, Lcn2 and Krt19 were identified and quantified as early and reliable biomarkers for chronic rejection.ConclusionAnalysis of differential protein expression by iTRAQ-MALDI-TOF/TOF is a potentially effective method to help understand the mechanism of CR in orthotopic liver transplantation. The proteins CLU, Lcn2 and Krt19 might be potential prognostic markers for predicting chronic rejection after liver transplantation.
