Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3286347 | Clinics and Research in Hepatology and Gastroenterology | 2014 | 4 Pages |
Abstract
SummaryHepatic fibrosis results from the accumulation of extracellular matrix-producing myofibroblasts in the liver. The mechanisms leading to the activation of hepatic stellate cells (HSCs) into myofibroblasts have been well described. By contrast, few molecular pathways leading to myofibroblast deactivation have been documented. Recently, the vitamin D-VDR axis has been shown to modulate HSC activity through a complex mechanism involving epigenetic modifications induced by the SMAD pathway.
Related Topics
Health Sciences
Medicine and Dentistry
Gastroenterology
Authors
D. Firrincieli, T. Braescu, C. Housset, N. Chignard,