| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3286435 | Clinics and Research in Hepatology and Gastroenterology | 2014 | 5 Pages |
Abstract
SummaryUncoupling of oxidative phosphorylation (OXPHOS) in brown adipose tissue can be used by hibernating animals to produce heat at the expense of their fat mass. In a recent work, Dr Shulman et al. generated a liver-targeted derivative of the prototypical OXPHOS uncoupler 2,4-dinitrophenol that alleviated steatosis, hypertriglyceridemia and insulin resistance in several models of nonalcoholic fatty liver disease and type 2 diabetes.
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Authors
B. Fromenty,