| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3291868 | Gastroenterology | 2016 | 26 Pages |
Abstract
In intestinal tissues of mice, PRC2 maintains small intestinal stem cells by promoting proliferation and preventing differentiation in the intestinal stem cell compartment. PRC2 controls gene expression in multiple signaling pathways that regulate intestinal homeostasis. Sequencing data are available in the genomics data repository GEO under reference series GSE81578; RNA sequencing data are available under subseries GSE81576; and ChIP sequencing data are available under subseries GSE81577.
Keywords
βNFFDRRNA-seqPRC1EEDH3K27me3CBCISCCGIPcGβ-naphthoflavonechromatin immunoprecipitationRNA sequencingfold changeembryonic ectoderm developmentCpG islandDevelopmentSmall intestinecrypt base columnarintestinal stem cellConditioned mediumfalse discovery rateknockoutwild typepolymerase chain reactionPCRCHiPpolycomb group
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Authors
Martijn A.J. Koppens, Gergana Bounova, Gaetano Gargiulo, Ellen Tanger, Hans Janssen, Paulien Cornelissen-Steijger, Marleen Blom, Ji-Ying Song, Lodewyk F.A. Wessels, Maarten van Lohuizen,