A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF

Article ID	Journal	Published Year	Pages	File Type
3291870	Gastroenterology	2016	16 Pages	PDF

Abstract

In a genetic analysis of Ashkenazi Jewish individuals, we associated CD with a frameshift mutation in CSF2RB. Intestinal monocytes from carriers of this mutation had reduced responses to granulocyte-macrophage colony-stimulating factor, providing an additional mechanism for alterations to the innate immune response in individuals with CD.

Keywords

granulocyte-macrophage colony–stimulating factor CyTOF PBS Ashkenazi Jewish GM-CSF HBSS IBD PCA Akt interleukin Crohn's disease Inflammatory bowel disease Principal component analysis ethnic variation Colorectal cancer Risk factor Phosphate-buffered saline Hank’s balanced salt solution Genome-wide association study GWAS PERK CRC Ulcerative colitis

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

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A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF

Authors

Ling-Shiang Chuang, Nicole Villaverde, Ken Y. Hui, Arthur Mortha, Adeeb Rahman, Adam P. Levine, Talin Haritunians, Sok Meng Evelyn Ng, Wei Zhang, Nai-Yun Hsu, Jody-Ann Facey, Tramy Luong, Heriberto Fernandez-Hernandez, Dalin Li, Manuel Rivas,