| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3291922 | Gastroenterology | 2016 | 26 Pages |
Abstract
In a 2-step forward genetic screen in mice, we identified members of the Ral guanosine triphosphatase-activating protein pathway and other proteins as suppressors of HCC cell proliferation and tumor growth. These proteins might serve as therapeutic targets for liver cancer.
Keywords
GTPaseTCGAmRNACISHBsAgshRNACCGGCIsTSGHCCmessenger RNASmall interfering RNAshort hairpin RNAsiRNAHepatitis B surface antigenThe cancer genome atlasSleeping BeautyLiver cancerKinase inhibitorHBVpolymerase chain reactionPCRhepatitis B virustumor-suppressor geneHepatocellular carcinomaguanosine triphosphatase
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Authors
Takahiro Kodama, Emilie A. Bard-Chapeau, Justin Y. Newberg, Michiko Kodama, Roberto Rangel, Kosuke Yoshihara, Jerrold M. Ward, Nancy A. Jenkins, Neal G. Copeland,