| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3292202 | Gastroenterology | 2016 | 46 Pages |
Abstract
We identified a mechanism of VEGF overexpression in liver and mesentery that promotes pathologic, but not physiologic, angiogenesis, via sequential and nonredundant functions of CPEB1 and CPEB4. Regulation of CPEB4 by CPEB1 and the CPEB4 autoamplification loop induces pathologic angiogenesis. Strategies to block the activities of CPEBs might be developed to treat chronic liver and other angiogenesis-dependent diseases.
Keywords
CPEBrapid amplification of complementary DNA endspolyadenylation sitePPVLshRNAmRNACPEaurora kinase ACytoplasmic polyadenylationmessenger RNAshort hairpin RNAAURKAcytoplasmic polyadenylation elementAU-rich elementVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)RaceUntranslated regionsUTR یا untranslated regions PASAREPortal hypertensionPartial portal vein ligation
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Authors
Vittorio Calderone, Javier Gallego, Gonzalo Fernandez-Miranda, Ester Garcia-Pras, Carlos Maillo, Annalisa Berzigotti, Marc Mejias, Felice-Alessio Bava, Ana Angulo-Urarte, Mariona Graupera, Pilar Navarro, Jaime Bosch, Mercedes Fernandez, Raul Mendez,