| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3292264 | Gastroenterology | 2015 | 23 Pages |
Abstract
Inhibition of VEGFR2 signaling leads to senescence of human and mouse colorectal cancer cells. VEGFR2 interacts with phosphatidylinositol-4,5-bisphosphate-3-kinase and AKT to inactivate p21. Colorectal tumor senescence and p21 level correlate with patient survival during treatment with bevacizumab.
Keywords
PI3KMVDqPCRazoxymethaneCACDSSVEGFR2AOMsenescence-associated β-galactosidaseAngiogenesisinflammationImmunohistochemistryIHCMicrovessel densityColorectal cancercolitis-associated cancerColon cancerintestinal epithelial cellEndothelial cellsdextran sodium sulfateVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Mouse modelquantitative polymerase chain reactionanti-tumor immune responseCRCIECvascular endothelial growth factor receptor 2
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Authors
Sebastian Foersch, Tobias Sperka, Christina Lindner, Astrid Taut, Karl L. Rudolph, Georg Breier, Frank Boxberger, Tilman T. Rau, Arndt Hartmann, Michael Stürzl, Nadine Wittkopf, Lisa Haep, Stefan Wirtz, Markus F. Neurath, Maximilian J. Waldner,