Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes

Article ID	Journal	Published Year	Pages	File Type
3292267	Gastroenterology	2015	22 Pages	PDF

Abstract

The transcription factor NRF2 binds to the promoter of ITPR3 to inhibit its expression in cholangiocytes, leading to reduced calcium signaling and bile duct secretion. This could be a mechanism by which oxidative stress inhibits these processes and contributes to cholangiopathies.

Keywords

histone H3 lysine 9 H3K9 ITPR ANIT H3K27 GCLC histone H3 lysine 27 HO-1 shRNA Nrf2 t-BHQ NHC mRNA ROI keap1 messenger RNA Small interfering RNA short-hairpin RNA siRNA Adenosine Triphosphate ATP tert-butyl hydroquinone Gene regulation Primary biliary cirrhosis mare region of interest Signal transduction heme oxygenase polymerase chain reaction PCR Glutamate cysteine ligase catalytic subunit Inositol 1,4,5-trisphosphate receptor IBDU

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

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Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes

Authors

Jittima Weerachayaphorn, Maria Jimena Amaya, Carlo Spirli, Piyachat Chansela, Kisha A. Mitchell-Richards, Meenakshisundaram Ananthanarayanan, Michael H. Nathanson,