Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3292267 | Gastroenterology | 2015 | 22 Pages |
Abstract
The transcription factor NRF2 binds to the promoter of ITPR3 to inhibit its expression in cholangiocytes, leading to reduced calcium signaling and bile duct secretion. This could be a mechanism by which oxidative stress inhibits these processes and contributes to cholangiopathies.
Keywords
histone H3 lysine 9H3K9ITPRANITH3K27GCLChistone H3 lysine 27HO-1shRNANrf2t-BHQNHCmRNAROIkeap1messenger RNASmall interfering RNAshort-hairpin RNAsiRNAAdenosine TriphosphateATPtert-butyl hydroquinoneGene regulationPrimary biliary cirrhosismareregion of interestSignal transductionheme oxygenasepolymerase chain reactionPCRGlutamate cysteine ligase catalytic subunitInositol 1,4,5-trisphosphate receptorIBDU
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Authors
Jittima Weerachayaphorn, Maria Jimena Amaya, Carlo Spirli, Piyachat Chansela, Kisha A. Mitchell-Richards, Meenakshisundaram Ananthanarayanan, Michael H. Nathanson,