| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3292445 | Gastroenterology | 2013 | 21 Pages |
Abstract
An inhibitor of the prostaglandin synthase TXAS inhibits production of infectious HCV particles in cultured hepatocytes and HCV infection of hepatocytes in mice with humanized livers. It therefore might be therapeutic for HCV infection.
Keywords
COXTXASThromboxane A2 synthaseProstaglandin I2 synthasePGISTXB2HCVccTxA2AACqRT-PCRRT-PCRmRNA3-dimensionalcAMPmessenger RNASmall interfering RNAsiRNAArachidonic acid cascadeCyclic adenosine monophosphatecyclooxygenasethromboxane B2Thromboxane A2Antiviral drug2-dimensionallipid dropletHCVHepatitis C virusLipid mediatorquantitative reverse-transcription polymerase chain reactionreverse-transcription polymerase chain reactionprostaglandinthromboxane A2 receptor
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Authors
Yuichi Abe, Hussein Hassan Aly, Nobuhiko Hiraga, Michio Imamura, Takaji Wakita, Kunitada Shimotohno, Kazuaki Chayama, Makoto Hijikata,