Nerve Fiber Outgrowth Is Increased in the Intestinal Mucosa of Patients With Irritable Bowel Syndrome

Article ID	Journal	Published Year	Pages	File Type
3292601	Gastroenterology	2015	14 Pages	PDF

Abstract

Nerve fiber density and sprouting, as well as expression of NGF and NTRK1, are significantly increased in mucosal tissues of patients with IBS. Mucosal mediators participate to these neuroplastic changes.

Keywords

NSE IBS-M TRPV-1 NTRK1 IBS-D IBS-C tyrosine kinase receptor A Gap43 NGF IBS Enteric nerves Retinoic acid irritable bowel syndrome with diarrhea irritable bowel syndrome with constipation irritable bowel syndrome nerve growth factor Mast cells growth-associated protein 43

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

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Nerve Fiber Outgrowth Is Increased in the Intestinal Mucosa of Patients With Irritable Bowel Syndrome

Authors

Giovanni Dothel, Maria Raffaella Barbaro, HélÃ¨ne Boudin, Valentina Vasina, Cesare Cremon, Luciana Gargano, Lara Bellacosa, Roberto De Giorgio, Catherine Le Berre-Scoul, Philippe Aubert, Michel Neunlist, Fabrizio De Ponti, Vincenzo Stanghellini,