| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3292602 | Gastroenterology | 2015 | 26 Pages |
Abstract
Disruption of Shp in mice alters timing of expression of genes that regulate homocysteine metabolism and the liver responses to ethanol and homocysteine. SHP inhibits the transcriptional activation of Bhmt and cystathionine γ-lyase by FOXA1.
Keywords
SAMS-adenosylhomocysteineSAHCThHcySHPHHcyBetaine-homocysteine S-methyltransferaseEtOHCTRLmRNAFoxA1BHMTcystathionine γ-lyasemessenger RNAEthanolS-adenosylmethionineCircadian regulationZeitgeber timesmall heterodimer partnerTranscription factorMetabolismMethionineMETwild-typehomocysteineHyperhomocysteinemiaControlNuclear receptor
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Authors
Hiroyuki Tsuchiya, Kerry-Ann da Costa, Sangmin Lee, Barbara Renga, Hartmut Jaeschke, Zhihong Yang, Stephen J. Orena, Michael J. Goedken, Yuxia Zhang, Bo Kong, Margitta Lebofsky, Swetha Rudraiah, Rana Smalling, Grace Guo, Stefano Fiorucci,