Use of Hy's Law and a New Composite Algorithm to Predict Acute Liver Failure in Patients With Drug-Induced Liver Injury

Article ID	Journal	Published Year	Pages	File Type
3292660	Gastroenterology	2014	15 Pages	PDF

Abstract

When applied at DILI recognition, the nR criteria for Hy's Law provides the best balance of sensitivity and specificity whereas our new composite algorithm provides additional specificity in predicting the ultimate development of ALF.

Keywords

tbl OLT AUROC INR ALF ULN ALT ROC AST Aspartate aminotransferase Drug-induced liver injury Alanine aminotransferase ALP Alkaline phosphatase Upper limit of normal DILI Idiosyncratic hepatotoxicity Area under receiver operating characteristic curve Acute liver failure ratio Likelihood ratio International Normalized Ratio Prediction Progression orthotopic liver transplantation total bilirubin receiver operating characteristic

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

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Use of Hy's Law and a New Composite Algorithm to Predict Acute Liver Failure in Patients With Drug-Induced Liver Injury

Authors

Mercedes Robles-Diaz, M. Isabel Lucena, Neil Kaplowitz, Camilla Stephens, Inmaculada Medina-Cáliz, Andres González-Jimenez, Eugenia Ulzurrun, Ana F. Gonzalez, M. Carmen Fernandez, Manuel Romero-Gómez, Miguel Jimenez-Perez, Miguel Bruguera,