| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3292669 | Gastroenterology | 2014 | 15 Pages |
Abstract
Monocytes sense cells that contain replicating HCV and respond by producing interleukin-18 via the inflammasome and by activating NK cells. Patients with chronic HCV infection have reduced monocyte function, attenuating NK cell IFN-γ-mediated responses.
Keywords
BPATLRIQRTNFPDCMFIPBMCFBSnatural killerE/TSmall interfering RNAsiRNAinterferonIFNinterleukinCytokine productionViral replicationToll-like receptorfetal bovine serumPeripheral blood mononuclear cellPlasmacytoid dendritic celltumor necrosis factorinterquartile rangemean fluorescence intensityHepatocyteHepatitis C virusHCVImmune response
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Authors
Elisavet Serti, Jens M. Werner, Michael Chattergoon, Andrea L. Cox, Volker Lohmann, Barbara Rehermann,