| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3292718 | Gastroenterology | 2013 | 25 Pages |
Abstract
MAGL modulates hepatic injury via endocannabinoid and eicosanoid signaling; blockade of this pathway protects mice from liver injury. MAGL inhibitors might be developed to treat conditions that expose the liver to oxidative stress and inflammatory damage.
Keywords
2-AGTNFarachidonoylglycerolGalNNPCALTLPSCOXmRNAI/Rmessenger RNAASTAspartate aminotransferaseAlanine aminotransferaseArachidonic acidischemia/reperfusionintraperitonealNonparenchymal cellsKupffer cellsCyclooxygenasesEndocannabinoid signalingSurgerytumor necrosis factormonoacylglycerol lipaselipopolysaccharideMouse modelcannabinoid receptor type 2
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Authors
Zongxian Cao, Melinda M. Mulvihill, Partha Mukhopadhyay, Huan Xu, Katalin Erdélyi, Enkui Hao, Eileen Holovac, György Haskó, Benjamin F. Cravatt, Daniel K. Nomura, Pál Pacher,