| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3292779 | Gastroenterology | 2015 | 27 Pages |
Abstract
Patients with ACLF have increased numbers of immunoregulatory monocytes and macrophages that express MERTK and suppress the innate immune response to microbes. The number of these cells correlates with disease severity and the inflammatory response. MERTK inhibitors restore production of inflammatory cytokines by immune cells from patients with ACLF, and might be developed to increase the innate immune response in these patients.
Keywords
ALFPMΦMer receptor tyrosine kinaseCLIFLITUACLFSIRSHUVECLPSCCRCLDSequential Organ Failure AssessmentinterleukinChronic liver diseasetumor necrosis factor αcluster of differentiationMERTKHuman umbilical vein endothelial cellSystemic inflammatory response syndromeBacterial infectionTNF-αlipopolysaccharidePeritoneal macrophageModel of End-stage Liver DiseaseImmune regulationacute-on-chronic liver failureAcute liver failureSOFAhealthy controlLymph nodeMELDchemokine receptor
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Authors
Christine Bernsmeier, Oltin T. Pop, Arjuna Singanayagam, Evangelos Triantafyllou, Vishal C. Patel, Christopher J. Weston, Stuart Curbishley, Fouzia Sadiq, Nikhil Vergis, Wafa Khamri, William Bernal, Georg Auzinger, Michael Heneghan, Yun Ma, Wayel Jassem,