| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3292837 | Gastroenterology | 2014 | 13 Pages |
Abstract
IL-1 signaling, via IL-1R1 and MyD88, is required for development of POI after intestinal manipulation in mice. Agents that interfere with the IL-1 signaling pathway are likely to be effective in the treatment of POI.
Keywords
mRNAInterleukin-1 receptor type IGFAPPOIIL-18RMCP-1IL-1RTLRIL-1R1IL-1RAMPOmessenger RNAIL-1 receptor antagonistgastrointestinal dysmotilityInnate immunityimmunoglobulin interleukinPathogen recognitionToll-like receptorGastrointestinalmyeloperoxidasewild-typeInflammatory responsemonocyte chemotactic protein 1Glial fibrillary acidic proteinInterleukin 1 receptorPostoperative ileus
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Authors
Burkhard Stoffels, Kristof Johannes Hupa, Susanne A. Snoek, Sjoerd van Bree, Kathy Stein, Timo Schwandt, Tim O. Vilz, Mariola Lysson, Cornelis van't Veer, Markus P. Kummer, Veit Hornung, Joerg C. Kalff, Wouter J. de Jonge, Sven Wehner,