| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3292842 | Gastroenterology | 2014 | 17 Pages |
Abstract
Expression of KrasG12D and SOX17 in mice induces development of metaplasias with a biliary phenotype containing tuft cells. Tuft cells express a number of tumorigenic factors that can alter the microenvironment. Expression of SOX17 induces pancreatitis and promotes KrasG12D-induced tumorigenesis in mice.
Keywords
EGFRDCLK1acinar-to-ductal metaplasiaperibiliary glandCOXPBGYFPPDAADMDAPI4′,6-diamidino-2-phenylindolePancreatic ductal adenocarcinomacyclooxygenaseImmunofluorescenceIHCImmunohistochemistryPancreatic cancerMouse modelPdGpancreatic intraepithelial neoplasiaSignal transductionPathogenesisPanINyellow fluorescent proteindoublecortin-like kinase 1Epidermal growth factor receptor
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Authors
Kathleen E. DelGiorno, Jason C. Hall, Kenneth K. Takeuchi, Fong Cheng Pan, Christopher J. Halbrook, M. Kay Washington, Kenneth P. Olive, Jason R. Spence, Bence Sipos, Christopher V.E. Wright, James M. Wells, Howard C. Crawford,