Hepatic Cannabinoid Receptor-1 Mediates Diet-Induced Insulin Resistance via Inhibition of Insulin Signaling and Clearance in Mice

Article ID	Journal	Published Year	Pages	File Type
3292900	Gastroenterology	2012	12 Pages	PDF

Abstract

Endocannabinoids contribute to diet-induced insulin resistance in mice via hepatic CB1-mediated inhibition of insulin signaling and clearance.

Keywords

STD GTP[γS]4-phenyl butyric acid PBA PEPCK CB1 HFD shRNA Jnk Small interfering RNA short hairpin RNA siRNA insulin-degrading enzyme standard chow IDE high-fat diet endoplasmic reticulum phosphoenolpyruvate carboxykinase Nash Signal transduction polymerase chain reaction PCR cannabinoid receptor-1

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

Preview

Hepatic Cannabinoid Receptor-1 Mediates Diet-Induced Insulin Resistance via Inhibition of Insulin Signaling and Clearance in Mice

Authors

Jie Liu, Liang Zhou, Keming Xiong, Grzegorz Godlewski, Bani Mukhopadhyay, Joseph Tam, Shi Yin, Peter Gao, Xin Shan, James Pickel, Ramon Bataller, James O'hare, Thomas Scherer, Christoph Buettner, George Kunos,