| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3292947 | Gastroenterology | 2012 | 10 Pages |
Abstract
We created gene-targeted pigs with mutations in the adenomatous polyposis coli (APC) gene (APC) that are orthologous to those responsible for human familial adenomatous polyposis (FAP). One-year-old pigs with the APC1311 mutation (orthologous to human APC1309) have aberrant crypt foci and low- and high-grade dysplastic adenomas in the large intestine, similar to the precancerous lesions that develop in patients with FAP. Dysplastic adenomas accumulate β-catenin and lose heterozygosity of APC. This large-animal, genetic model of FAP will be useful in the development of diagnostics and therapeutics for colorectal cancer. DNA sequence data: NCBI accession number GU951771.
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Authors
Tatiana Flisikowska, Claudia Merkl, Martina Landmann, Stefan Eser, Nousin Rezaei, Xinxin Cui, Mayuko Kurome, Valeri Zakhartchenko, Barbara Kessler, Hagen Wieland, Oswald Rottmann, Roland M. Schmid, Günter Schneider, Alexander Kind, Eckhard Wolf,