| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293024 | Gastroenterology | 2018 | 14 Pages |
Abstract
We identified post-translational modifications (S-nitrosylation of cysteine residues 199 and 304) in the cytoplasmic domain of Fas. S-nitrosylation at cysteine 304 promotes redistribution of Fas to lipid rafts, formation of the death-inducing signal complex, and induction of cell death.
Keywords
GTNSNOGFPFADDNOSDISCCys3-dimensionalLocalizationTumorFas-associated death domainAlpsColon cancerautoimmune lymphoproliferative syndromeCysteineSignalingFas-ligandFasLFLICEwild-typeNitrosothiolNitric oxidenitric oxide synthasegreen fluorescent proteindeath-inducing signaling complexGlyceryl trinitrate
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Authors
Lissbeth Leon-Bollotte, Selvakumar Subramaniam, Olivier Cauvard, Stéphanie Plenchette-Colas, Catherine Paul, Cindy Godard, Antonio Martinez-Ruiz, Patrick Legembre, Jean-François Jeannin, Ali Bettaieb,