| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293096 | Gastroenterology | 2012 | 20 Pages |
Abstract
Expression of RBPMS2 is present in visceral SMC precursors. Sustained expression of RBPMS2 inhibits the expression of markers of SMC differentiation by inhibiting bone morphogenetic protein activity, and stimulates SMC proliferation. RBPMS2 transcripts are up-regulated in patients with CIPO; alterations in RBPMS2 function might be involved in digestive motility disorders, particularly those characterized by the presence of muscular lesions (visceral myopathies).
Keywords
qPCRfour and a half LIM domains 2SM-MHCphosphorylated SmadSM22RCASpSmadRRMFHL2αSMAPH3RBPENSHSCRSRFDMEMSMCmRNAICCGFPDulbecco's modified Eagle Mediump-Aktmessenger RNARNA recognition motifSmooth muscle contractionα-smooth muscle actinHirschsprung diseaseShhGastrointestinal tractembryonic daySmooth muscle myosin heavy chainDevelopmental biologySmooth muscle cellinterstitial cells of Cajalenteric nervous systemChronic intestinal pseudo-obstructionsonic hedgehogserum response factorphosphorylated AktBMPCIPOquantitative polymerase chain reactiongreen fluorescent proteinRNA-binding proteinBone morphogenetic protein
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Authors
Cécile Notarnicola, Caroline Rouleau, Ludovic Le Guen, Anne Virsolvy, Sylvain Richard, Sandrine Faure, Pascal De Santa Barbara,