Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

Article ID	Journal	Published Year	Pages	File Type
3293103	Gastroenterology	2012	15 Pages	PDF

Abstract

IL-17 induces liver fibrosis through multiple mechanisms in mice. Reagents that block these pathways might be developed as therapeutics for patients with cirrhosis.

Keywords

CCl4 TNF aHSCs c-Jun-N-terminal kinase HSCs TGF BDL NF-κB ERK α-SMA Jnk mRNA PMA messenger RNA α-smooth muscle actin interleukin transforming growth factor Kupffer cells Endothelial cells Hepatic stellate cells tumor necrosis factor nuclear factor-κB Bone marrow-derived macrophages Mouse model bone marrow Myofibroblast Immune response bile duct ligation Carbon tetrachloride extracellular signal-regulated kinase

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Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

Authors

Fanli Meng, Kai Wang, Tomonori Aoyama, Sergei I. Grivennikov, YongHan Paik, David Scholten, Min Cong, Keiko Iwaisako, Xiao Liu, Mingjun Zhang, Christoph H. Ãsterreicher, Felix Stickel, Klaus Ley, David A. Brenner, Tatiana Kisseleva,