Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3293104 | Gastroenterology | 2012 | 16 Pages |
Abstract
Differences in expression of ISGs might account for the greater response of patients with AHC, compared with those with CHC, to treatment with pegIFN-α and ribavirin. Specifically, USP18 is up-regulated in liver samples of patients with CHC that did not respond to therapy, but not in patients with AHC.
Keywords
MAVSpegylated interferon alfaISGPHHCHCPegIFN-αhpfAHCpStat1mRNASVRPhosphorylated STAT1Janus kinaseprimary human hepatocytesmessenger RNAreverse-transcriptionhigh-power fieldchronic hepatitis CAcute hepatitis CHepatitis C virusHCVpolymerase chain reactionPCRSustained virologic responseImmune responsemitochondrial antiviral signaling proteinJAKinterferon-stimulated gene
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Authors
Michael T. Dill, Zuzanna Makowska, Francois H.T. Duong, Franzisca Merkofer, Magdalena Filipowicz, Thomas F. Baumert, Luigi Tornillo, Luigi Terracciano, Markus H. Heim,