Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3293105 | Gastroenterology | 2012 | 25 Pages |
Abstract
Reduced expression of GNMT in mouse hepatoma cells and human HCC cells appears to increase activity of LKB1 and RAS; activation of RAS signaling to LKB1 and RASGRP3, via ERK and p90RSK, might be involved in liver carcinogenesis and be used as a prognostic marker. Reagents that disrupt this pathway might be developed to treat patients with HCC.
Keywords
LKB1Ca2+/calmodulin-dependent protein kinase kinaseCaMKK2GNMTCaMKKDnmtpKaAMPKGTPAMPDNA methyltransferaseSmall interfering RNAsiRNAS-adenosylmethionineLiver cancerMatmethionine adenosyltransferaseMouse modelknockoutwild-typeprotein kinase Aliver kinase B1glycine N-methyltransferaseGuanosine triphosphateSAMe
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Authors
Nuria MartÃnez-López, Juan L. GarcÃa-RodrÃguez, Marta Varela-Rey, Virginia Gutiérrez, David Fernández-Ramos, Naiara Beraza, Ana M. Aransay, Karin Schlangen, Juan Jose Lozano, Patricia Aspichueta, Zigmund Luka, Conrad Wagner, Matthias Evert,