Article ID Journal Published Year Pages File Type
3293105 Gastroenterology 2012 25 Pages PDF
Abstract
Reduced expression of GNMT in mouse hepatoma cells and human HCC cells appears to increase activity of LKB1 and RAS; activation of RAS signaling to LKB1 and RASGRP3, via ERK and p90RSK, might be involved in liver carcinogenesis and be used as a prognostic marker. Reagents that disrupt this pathway might be developed to treat patients with HCC.
Related Topics
Health Sciences Medicine and Dentistry Gastroenterology
Authors
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