| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293106 | Gastroenterology | 2012 | 14 Pages |
Abstract
KLF4 binds to the promoter of VDR to regulate its expression; levels of KLF4 are reduced and levels of VDR are increased in HCC cell lines and primary tumor samples. Expression of KLF4 in HCC cells sensitizes them to the anti-proliferative effects of VD3. This pathway might be manipulated to prevent or treat liver cancer.
Keywords
KLF4VDRCDKN2ATMAeGFPCDH1VD3HCCmesenchymal-epithelial transitionReverse transcriptaseTranscriptional regulationretinoblastomaKrüppel-like factor 4phosphatase and tensin homologMETcyclin-dependent kinase inhibitor 2ATissue microarraypolymerase chain reactionPCRenhanced green fluorescent proteinPtencadherin-1Hepatocellular carcinomaVitamin D receptorNuclear receptor
Related Topics
Health Sciences
Medicine and Dentistry
Gastroenterology
Authors
Qi Li, Yong Gao, Zhiliang Jia, Lopa Mishra, Kun Guo, Zhiwei Li, Xiangdong Le, Daoyan Wei, Suyun Huang, Keping Xie,