| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293200 | Gastroenterology | 2014 | 19 Pages |
Abstract
In KRAS-dependent PDAC cell lines, HNRNPA2B1 interacts with and regulates the activity of KRAS G12V and G12D. HNRNPA2B1 is required for KRAS activation of c-akt murine thymoma oncogene homolog 1-mammalian target of rapamycin signaling, interaction with phosphatidylinositide 3-kinase, and PDAC cell survival and tumor formation in mice. HNRNPA2B1 might be a target for treatment of pancreatic cancer.
Keywords
PI3KGTPKRASGFPhnRNPshRNAmTORPKCFCSsmall hairpin RNAPancreatic ductal adenocarcinomaPDAC یا pancreatic ductal adenocarcinomaAktsodium dodecyl sulfate-polyacrylamide gel electrophoresisSDS-PAGEOncogeneheterogeneous nuclear ribonucleoproteinCarcinogenesisfetal calf serumphosphatidylinositide 3-kinaseMouse modelSignal transductionmammalian target of rapamycinhemagglutiningreen fluorescent proteinProtein kinase CGuanosine triphosphate
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Authors
Carles Barceló, Julia Etchin, Marc R. Mansour, Takaomi Sanda, Mireia M. Ginesta, Victor J. Sanchez-Arévalo Lobo, Francisco X. Real, Gabriel Capellà , Josep M. Estanyol, Montserrat Jaumot, A. Thomas Look, Neus Agell,