| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293273 | Gastroenterology | 2013 | 19 Pages |
Abstract
mDC2s are a major source of IFN-λ production by PBMCs in response to HCVcc/Huh7.5 cells. mDC2s are activated through the TLR3 pathway, indicating that human DCs efficiently can initiate an immune response against HCV infection. IFN-λ therefore has an important role in HCV infection.
Keywords
PBMCHCVccNKTPHHISGJFH-1dsRNARLRCXCLBDCAPRRCXC-chemokine ligandTLRCpGmRNAPDCDouble-strand RNAssRNAMDCnatural killerprimary human hepatocytesMx1messenger RNAinterferonIFNinterleukinregulated on activation, normal T cell expressed and secretedToll-like receptorPeripheral blood mononuclear cellDendritic cellPlasmacytoid dendritic cellMyeloid dendritic cellNK cellsNKT cellsCytosine-phosphate-guanosinenatural killer TTRAILTNF-related apoptosis-inducing ligandRANTESHepatitis C virusHCVinterferon-inducible proteinSingle-nucleotide polymorphismSNPinterferon-stimulated genePRR, Pattern recognition receptor
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Authors
Shuye Zhang, Karen Kodys, Kui Li, Gyongyi Szabo,