| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293275 | Gastroenterology | 2013 | 16 Pages |
Abstract
Oxidative metabolism of ethanol sensitizes pancreatic mitochondria to activate MPTP, leading to mitochondrial failure; this makes the pancreas susceptible to necrotizing pancreatitis.
Keywords
ALDHtetramethylrhodamineΔΨmCholecystokinin-8MPTPCCKBALADHCyclophilin DFAEETMRMMMPCypDNAD+[Ca2+]iAdenosine TriphosphateATPTissue damagealdehyde dehydrogenasefatty acid ethyl esterAlcohol dehydrogenasemitochondrial permeability transition poreoxidized nicotinamide adenine dinucleotideblood alcohol levelEthanol toxicityCell deathNADHMitochondrial membrane permeabilizationExocrine PancreasMitochondrial membrane potentialreduced nicotinamide adenine dinucleotide
Related Topics
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Authors
Natalia Shalbueva, Olga A. Mareninova, Andreas Gerloff, Jingzhen Yuan, Richard T. Waldron, Stephen J. Pandol, Anna S. Gukovskaya,