| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293328 | Gastroenterology | 2012 | 18 Pages |
Abstract
GITR is not required on the surface of Treg and T effector cells to induce colitis in mice; interactions between GITR and its ligand are not required for induction of colitis. GITR instead appears to control dendritic cell and monocyte development; in its absence, mice develop aggravated chronic enterocolitis via an imbalance of colitogenic Th1 cells and Treg cells.
Keywords
FACSTNFMLNGITRT-helperDAIIDOAPCOVAIBDFITCPDCantigen-presenting cellinflammationOvalbumininterferonIFNinterleukinindoleamine 2,3-dioxygenaseTefffluorescence-activated cell sortingeffector T cellRegulatory T cellTreg cellDendritic cellPlasmacytoid dendritic celldisease activity indexfluorescein isothiocyanateImmune regulationwild-typemesenteric lymph node
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Authors
Gongxian Liao, Cynthia Detre, Scott B. Berger, Pablo Engel, Rene de Waal Malefyt, Roland W. Herzog, Atul K. Bhan, Cox Terhorst,