| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293332 | Gastroenterology | 2012 | 16 Pages |
Abstract
Cdc25A inhibitors block cell-cycle progression and proliferation, reduce liver and kidney weights and cyst growth in animal models of polycystic kidney disease and PLD, and might be developed as therapeutics for these diseases.
Keywords
PLDPCNAPKHD1Cdc25PKDPCKPKD2ADPKDARPKDCDK3-D3-dimensionalProliferating Cell Nuclear AntigenTherapeutic strategypolycystic liver diseasepolycystic kidney diseaseautosomal-dominant polycystic kidney diseaseautosomal-recessive polycystic kidney diseaseCell divisionretinoblastomacell division cycle 25PhosphataseAnimal modelpolymerase chain reactionPCRVitamin K3polycystic kidneycyclin-dependent kinase
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Authors
Tatyana V. Masyuk, Brynn N. Radtke, Angela J. Stroope, Jesús M. Banales, Anatoliy I. Masyuk, Sergio A. Gradilone, Gabriella Bedekovicsne Gajdos, Natasha Chandok, Jason L. Bakeberg, Christopher J. Ward, Erik L. Ritman, Hiroaki Kiyokawa,