Pro-Angiogenic Activity of TLRs and NLRs: A Novel Link Between Gut Microbiota and Intestinal Angiogenesis

Article ID	Journal	Published Year	Pages	File Type
3293392	Gastroenterology	2013	20 Pages	PDF

Abstract

The gut microbiota can selectively activate mucosal endothelial and mesenchymal cells to promote specific angiogenic responses in a TLR- and NOD-like receptor-dependent fashion. This innate immunity-mediated response may expand the mucosal microvascular network, foster immune cell recruitment, and contribute to chronic intestinal inflammation.

Keywords

IBD human intestinal microvascular endothelial cell HIMEC MIP-1α RIP2 NLR PDGF TRAF6 HIF VEGF-R2 TLR MCP-1 FAK FBS bFGF DMEM NOD GFP LPS mRNA MAPK messenger RNA Small interfering RNA siRNA Angiogenesis interleukin Inflammatory bowel disease tumor necrosis factor α Toll-like receptor Dulbecco's minimal essential medium nucleotide-binding oligomerization domain fetal bovine serum Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)platelet-derived growth factor basic fibroblast growth factor TNF-α lipopolysaccharide ligand Macrophage inflammatory protein-1α monocyte chemoattractant protein-1 green fluorescent protein mitogen-activated protein kinase focal adhesion kinase Nod-like receptor vascular endothelial growth factor receptor 2