| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293614 | Gastroenterology | 2011 | 18 Pages |
Abstract
HER2 interaction with CD44 up-regulates CXCR4 by inhibiting expression of miR-139, at the epigenetic level, in gastric cancer cells. These findings indicate how HER2 signaling might promote gastric tumor progression and metastasis.
Keywords
miR-139HER2TSAmRNAMTA1H3K9HDACqRT-PCRHRGCXCR4GSPPBAmessenger RNASmall interfering RNAsiRNAGene-specific primer4-phenylbutyric acidheregulinTrichostatin AMicroRNAMiRNAC-X-C chemokine receptor type 4histone deacetylasequantitative reverse-transcription polymerase chain reactionHuman epidermal growth factor receptor 2
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Authors
Wei Bao, Hai-Jing Fu, Qiao-Sheng Xie, Lei Wang, Rui Zhang, Zhang-Yan Guo, Jing Zhao, Yan-Ling Meng, Xin-Ling Ren, Tao Wang, Qing Li, Bo-Quan Jin, Li-Bo Yao, Rui-An Wang, Dai-Ming Fan, Si-Yi Chen, Lin-Tao Jia, An-Gang Yang,