Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3293615 | Gastroenterology | 2011 | 11 Pages |
Abstract
In the human submucous plexus, PAR1, rather than PAR2 or PAR4, activates nerves and glia. These findings indicate that PAR1 should be the focus of future studies on neural PAR-mediated actions in the human intestine; PAR1 might be developed as a therapeutic target for gastrointestinal disorders associated with increased levels of proteases.
Keywords
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Authors
Kerstin Mueller, Klaus Michel, Dagmar Krueger, Ihsan Ekin Demir, Güralp Onur Ceyhan, Florian Zeller, Martin E. Kreis, Michael Schemann,