Article ID Journal Published Year Pages File Type
3293628 Gastroenterology 2011 18 Pages PDF
Abstract
Trypsin reduces pancreatic ductal bicarbonate secretion via PAR-2-dependent inhibition of the apical anion exchanger and the CFTR Cl− channel. This could contribute to the development of chronic pancreatitis by decreasing luminal pH and promoting premature activation of trypsinogen in the pancreatic ducts.
Related Topics
Health Sciences Medicine and Dentistry Gastroenterology
Authors
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