| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293677 | Gastroenterology | 2013 | 13 Pages |
Abstract
Accumulation of cholesterol in lysosomes of Kupfer cells promotes hepatic inflammation in mice. The cholesterol derivative 27HC reduces accumulation of cholesterol in lysosomes and might be used to treat non-alcoholic steatohepatitis.
Keywords
NAFLDTNFHFCALTMCP-127HCLDLRliver-X receptorLALCOL1A1CTXNPCLXRalanine aminotransferasesNon-alcoholic steatohepatitisinterleukinnon-alcoholic fatty liver diseaseTriglyceridesCerebrotendinous xanthomatosisKupffer cellMetabolic syndrometumor necrosis factorlysosomal acid lipaseMouse modelNash Niemann-Pick type Cwild typemonocyte chemoattractant protein 1transplantedFatty liverLow-density lipoprotein receptor
Related Topics
Health Sciences
Medicine and Dentistry
Gastroenterology
Authors
Veerle Bieghs, Tim Hendrikx, Patrick J. van Gorp, Fons Verheyen, Yasmin Dias Guichot, Sofie M.A. Walenbergh, Mike L.J. Jeurissen, Marion Gijbels, Sander S. Rensen, Aalt Bast, Jogchum Plat, Satish C. Kalhan, Ger H. Koek, Eran Leitersdorf,