| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293678 | Gastroenterology | 2013 | 17 Pages |
Abstract
CHD1L activates expression of SPOCK1, which activates Akt signaling to block apoptosis and invasion by HCC cells, in culture and in mice. Levels of SPOCK1 increase with progression of human HCC. SPOCK1 might be used as a prognostic factor or therapeutic target.
Keywords
STSqRT-PCRSPARCSPOCK1shRNABCL2-associated agonist of cell deathmRNAAJCCMMPSnf2PI3KPARPcDNAComplementary DNAHCCmessenger RNAshort hairpin RNAstaurosporinechromatin immunoprecipitationIHCImmunohistochemistryBADterminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labelingoverall survivalGene regulationTUNELbase pairDigoxinLiver cancerDIGPhosphatidylinositol 3-kinasematrix metallopeptidaseSignal transductionquantitative real-time polymerase chain reactionTumor progressionCHiPHepatocellular carcinomaAmerican Joint Committee on Cancer
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Authors
Yan Li, Leilei Chen, Tim Hon Man Chan, Ming Liu, Kar-Lok Kong, Ji-Liang Qiu, Yan Li, Yun-Fei Yuan, Xin-Yuan Guan,