| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293729 | Gastroenterology | 2011 | 13 Pages |
Abstract
The addition of SAMe to peginterferon and ribavirin improves the early viral kinetics and increases ISG induction in nonresponders to previous therapy. SAMe might be a useful adjunct to peginterferon-based therapies in chronic HCV infection.
Keywords
ISGPIASRSAD2ISGF3cEVRPeginterferonDMASVRPBMCJanus kinaseMx1S-adenosyl methionineStat1ViperinPegylated interferonPeripheral blood mononuclear cellInterferon signalingTranscription factorinterferon-stimulated gene factor 3Signal transducer and activator of transcriptionChronic hepatitispolymerase chain reactionPCRsustained virological responsecomplete early virological responseJAKinterferon-stimulated geneSAMe
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Authors
Jordan J. Feld, Apurva A. Modi, Ramy El-Diwany, Yaron Rotman, Emmanuel Thomas, Golo Ahlenstiel, Rachel Titerence, Christopher Koh, Vera Cherepanov, Theo Heller, Marc G. Ghany, Yoon Park, Jay H. Hoofnagle, T. Jake Liang,