| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293744 | Gastroenterology | 2011 | 19 Pages |
Abstract
Long-term ethanol feeding causes oxidative ER stress, which activates a UPR and increases XBP1 levels and activity. A defective UPR due to XBP1 deficiency results in ER dysfunction and acinar cell pathology.
Keywords
IRE1sXBP1Cholecystokinin-octapeptidespliced X-box binding protein 1Erdj4EDEM1organelleeIF2αXBP1PDIUPRGSSGCCK-8ATF4ERADAMSRT-PCRGSHGAPDHC/EBP homologous proteinterminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labelingTUNELCHOPendoplasmic reticulumeukaryotic translation initiation factor 2αTranscription factorsactivating transcription factor 4reverse-transcription polymerase chain reactionUnfolded protein responseX-box binding protein 1protein disulfide isomerasePERKGlutathioneglutathione disulfideglyceraldehyde-3-phosphate dehydrogenase
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Authors
Aurelia Lugea, David Tischler, Janie Nguyen, Jun Gong, Ilya Gukovsky, Samuel W. French, Fred S. Gorelick, Stephen J. Pandol,