| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293747 | Gastroenterology | 2011 | 21 Pages |
Abstract
IL28B genotype and hepatic expression of ISGs are independent predictors of response to treatment with pegIFN-α and ribavirin in patients with chronic hepatitis C. The most accurate prediction of response was obtained with a 4-gene classifier comprising IFI27, ISG15, RSAD2, and HTATIP2.
Keywords
CHCJAK-STAT signalingPegIFNRVRISGERRGAPDHSVRPBMCROCAUCInnate immunityPegylated interferonHost-virus interactionPeripheral blood mononuclear cellarea under the curveerror ratechronic hepatitis CHepatitis C virusrapid virologic responseSustained virologic responseSingle nucleotide polymorphismSNPinterferon-stimulated geneglyceraldehyde-3-phosphate dehydrogenasereceiver operating characteristic
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Authors
Michael T. Dill, Francois H.T. Duong, Julia E. Vogt, Stéphanie Bibert, Pierre-Yves Bochud, Luigi Terracciano, Andreas Papassotiropoulos, Volker Roth, Markus H. Heim,