Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3293798 | Gastroenterology | 2012 | 5 Pages |
Abstract
We performed a randomized trial to compare nebulized and viscous topical corticosteroid treatments for eosinophilic esophagitis (EoE). Subjects with incident EoE (n = 25) received budesonide 1 mg twice daily, either nebulized and then swallowed (NEB) or as an oral viscous slurry (OVB), for 8 weeks. Baseline eosinophil counts for the NEB and OVB groups were 101 and 83 (P = .62). Posttreatment counts were 89 and 11 (P = .02). The mucosal medication contact time, measured by scintigraphy, was higher for the OVB group than the NEB group (P < .005) and was inversely correlated with eosinophil count (R = â0.67; P = .001). OVB was more effective than NEB in reducing numbers of esophageal eosinophils in patients with EoE. OVB provided a significantly higher level of esophageal exposure to the therapeutic agent, which correlated with lower eosinophil counts.
Keywords
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Authors
Evan S. Dellon, Arif Sheikh, Olga Speck, Kimberly Woodward, Ann B. Whitlow, Jessica M. Hores, Marija Ivanovic, Allen Chau, John T. Woosley, Ryan D. Madanick, Roy C. Orlando, Nicholas J. Shaheen,