| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293857 | Gastroenterology | 2012 | 5 Pages |
Abstract
Large granular lymphocyte leukemia (LGL) is characterized by clonal expansion of CD3+ T cells or CD3â natural killer cells and frequently is associated with autoimmune diseases. We describe 2 patients with celiac disease who no longer responded to gluten-free diets after they developed T-cell LGL, with intestinal localization of malignant lymphocytes. Flow cytometry phenotyping of isolated intestinal intraepithelial and lamina propria cells eliminated type II refractory celiac disease, identifying large-sized CD8+CD57+ T cells. Treatment with a combination of cyclosporine and methotrexate restored the patients' sensitivity to gluten-free diets. LGL therefore might be a cause of refractory celiac disease that is sensitive to immunosuppressive therapy.
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Authors
Georgia Malamut, Bertrand Meresse, Virginie Verkarre, Sophie Kaltenbach, Nicolas Montcuquet, Jean-Paul Duong Van Huyen, Céline Callens, Julien Lenglet, Gabriel Rahmi, Elia Samaha, Brigitte Ranque, Elizabeth Macintyre, Isabelle Radford-Weiss,