| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293865 | Gastroenterology | 2012 | 18 Pages |
Abstract
Slamf1 contributes to the development of colitis in mice. It appears to indirectly regulate the appearance of monocytes and macrophages in inflamed intestinal tissues. Antibodies that inhibit Slamf1 reduce colitis in mice, so human SLAMF1 might be a therapeutic target for inflammatory bowel disease.
Keywords
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Gastroenterology
Authors
Boaz van Driel, Gongxian Liao, Xavier Romero, Michael S. O'Keeffe, Guoxing Wang, William A. Faubion, Scott B. Berger, Erica M. Magelky, Monika Manocha, Veronica Azcutia, Matthew Grisham, Francis W. Luscinskas, Emiko Mizoguchi, Rene de Waal Malefyt,