| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293871 | Gastroenterology | 2012 | 15 Pages |
Abstract
Significant parenchymal injury is not required for liver failure to develop after extended hepatectomy. Rather, liver dysfunction after eHx results from a transient, p21-dependent block before hepatocyte division. Therefore, a deficiency in cell-cycle progression causes liver failure after extended hepatectomy and can be overcome by inhibition of p21.
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Authors
Kuno Lehmann, Christoph Tschuor, Andreas Rickenbacher, Jae-Hwi Jang, Christian E. Oberkofler, Oliver Tschopp, Simon M. Schultze, Dimitri A. Raptis, Achim Weber, Rolf Graf, Bostjan Humar, Pierre-Alain Clavien,