| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293873 | Gastroenterology | 2012 | 19 Pages |
Abstract
Glucocorticoids promote hepatic cholestasis in mice by recruiting CtBP co-repressor complexes to FXR and thereby blocking the transcriptional activity.
Keywords
FXREGREFXRALTSHPcytochrome P450, family 7, subfamily a, polypeptide 1CtBPGSTshRNAmRNACYP7A1DEXCYP8B1farnesoid X receptormessenger RNAsmall hairpin RNAAlanine aminotransferaseBile acidchromatin immunoprecipitationLiver diseaseDexamethasonebody mass indexBMIsmall heterodimer partnerBile acid metabolismC-terminal binding proteinCHiPglutathione-S-transferaseGlucocorticoidglucocorticoid receptorNuclear receptor
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Authors
Yan Lu, Zhijian Zhang, Xuelian Xiong, Xiaolin Wang, Jin Li, Guojun Shi, Jian Yang, Xianfeng Zhang, Huijie Zhang, Jie Hong, Xuefeng Xia, Guang Ning, Xiaoying Li,