| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3293943 | Gastroenterology | 2010 | 14 Pages |
Abstract
HIF-1α protects the intestinal mucosa from C difficile toxins. The innate protective actions of HIF-1α in response to C difficile toxins be developed as therapeutics for C difficile-associated disease.
Keywords
NF-κBPHDPMNDMOGHRECDADHIF-1mRNATcdBdimethyloxaloylglycinel-NAMEmessenger RNAl-nitro-arginine methyl esterinterleukinToxin Atoxin BTERTcdAPolymorphonuclear cellsintestinal trefoil factorhypoxia-responsive elementhypoxia-inducible factor-1Vascular endothelial growth factortumor necrosis factornuclear factor-κBLamina propriaTransepithelial resistancenitric oxide synthasepolymerase chain reactionPCRprolyl hydroxylases
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Authors
Simon A. Hirota, Kyla Fines, Jeffrey Ng, Danya Traboulsi, Josh Lee, Eikichi Ihara, Yan Li, William G. Willmore, Daniel Chung, Melanie M. Scully, Thomas Louie, Shaun Medlicott, Manigandan Lejeune, Kris Chadee, Glen Armstrong, Sean P. Colgan,