| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3294012 | Gastroenterology | 2012 | 21 Pages |
Abstract
The HDAC inhibitor LBH589 can overcome the resistance of mouse gastric cancer cells to anthracyclines by inducing expression of CITED2. Levels of CITED2 in gastric tumors correlate with patients' response to epirubicin. LBH589 might be used to increase the response of patients to anthracyclines.
Keywords
mRNAEpirubicinIC50EPIECFHDAC3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromidecDNAComplementary DNAMTTmessenger RNASmall interfering RNAsiRNAchromatin immunoprecipitationempty vectorCancer treatmentCited2Chemotherapeutic agentStomachhalf-maximal inhibitory concentrationhistone deacetylaseCHiP
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Authors
Ivonne Regel, Lisa Merkl, Teresa Friedrich, Elke Burgermeister, Wolfgang Zimmermann, Henrik Einwächter, Ken Herrmann, Rupert Langer, Christoph Röcken, Ralf Hofheinz, Roland Schmid, Matthias P. Ebert,