| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3294017 | Gastroenterology | 2012 | 19 Pages |
Abstract
An RNA aptamer that binds to the PELPK sequence in CEA inhibits its interactions with heterogeneous nuclear ribonucleoprotein M4 and death receptor 5, migration and invasion by colon cancer cells, and hepatic metastasis of colon cancer cells in mice. It promoted cancer cell anoikis and might be used to identify CEA-positive tumors in patients or be developed as an anti-cancer reagent.
Keywords
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Gastroenterology
Authors
Young Ju Lee, Seung Ryul Han, Nam Yeon Kim, Soo-Han Lee, Jin-Sook Jeong, Seong-Wook Lee,