| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3294021 | Gastroenterology | 2012 | 18 Pages |
Abstract
The HBV protein HBx up-regulates PAK1, allows hepatoma cells to become resistant to anoikis, and promotes growth of aggressive xenograft tumors in mice. HBx induction of PAK1 might promote progression of HCC in patients with chronic HBV infection.
Keywords
RT-PCRPVTTHBxPAKHCCMcl1Small interfering RNAsiRNAterminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labelingportal vein tumor thrombosismyeloid cell leukemia sequence 1TUNELLiver cancerMetastasisMouse modelhepatitis B virus X proteinHBVreverse transcription polymerase chain reactionhepatitis B virusPropidium iodideHepatocellular carcinomap21-activated kinase
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Authors
Jiejie Xu, Haiou Liu, Lin Chen, Shanshan Wang, Lei Zhou, Xiaojing Yun, Linlin Sun, Yumei Wen, Jianxin Gu,